Journal
ONCOIMMUNOLOGY
Volume 3, Issue 8, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/21624011.2014.952201
Keywords
Galectin-1; immune evasion; immunosurveillance; pancreatic cancer; stroma; tumor microenvironment
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The tumor microenviroment and immune barrier are known to modulate malignant disease progression. We have recently identified Galectin-1 as a key player in a novel stromal regulatory reaction driving immune evasion in pancreatic tumors in vivo. These results suggest that Galectin-1 inhibition represents a potential therapeutic strategy for one of the most deadly types of cancer.
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