Journal
ONCOIMMUNOLOGY
Volume 3, Issue 10, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/21624011.2014.955709
Keywords
cancer immunotherapy; dendritic cell activation; immune checkpoint inhibitor; scavenger receptor MARCO; Toll-like receptor
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Whereas macrophages use the scavenger receptor MARCO primarily in antimicrobial immunity by interacting with both exogenous and endogenous environments, in dendritic cells (DCs) MARCO is believed to pleiotropically link innate to adaptive immunity. MARCO exerts a significant modulatory effect on TLR-induced DC activation, thus offering novel avenues in cancer immunotherapy.
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