Journal
ONCOIMMUNOLOGY
Volume 2, Issue 7, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.24891
Keywords
IL-6; immunosuppression; myeloid-derived suppressor cells; pancreatic cancer stellate cells; STAT3
Categories
Funding
- Prometheus, Inc.
- Karyopharm Therapeutics, Inc.
- Oncolytics, Inc.
- NIH [1R01 CA169363-01, 1R21 CA173473-01]
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Pancreatic cancer-associated stellate cells secrete soluble factors, such as interleukin-6 (IL-6), that promote the accumulation of myeloid-derived suppressor cells via a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. Targeting components of the IL-6/JAK/STAT3 signaling axis within the tumor stroma could therefore inhibit local immunosuppression and improve the efficacy of immunotherapeutic regimens against pancreatic cancer.
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