Journal
ONCOIMMUNOLOGY
Volume 2, Issue 11, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.26383
Keywords
glycolysis; ketogenic diet; lactate; MDSCs; NK cells
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Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby improving their immunological profile.
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