Journal
ONCOIMMUNOLOGY
Volume 2, Issue 3, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.23139
Keywords
IL1; NLRP3; fluorouracil; inflammasome; myeloid derived suppressor cells
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Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting T(H)17 responses that compromise anticancer immunity. This underscores the need to combine 5-FU with NLRP3 inhibitors to prevent tumor progression.
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