Journal
ONCOIMMUNOLOGY
Volume 2, Issue 12, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.27186
Keywords
aging; cancer immunotherapy; inflammation; macrophage; organ damage; pro-inflammatory cytokines; TNF alpha
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Cancer immunotherapy holds great promise, yet its efficacy and applicability can be hampered by the rise of systemic toxicities. We have recently shown that the lethal side effects of cancer immunotherapy are markedly exacerbated with aging. Blocking tumor necrosis factor alpha or macrophages can alleviate the systemic toxicity of immunotherapy while preserving its antineoplastic effects.
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