Journal
ONCOIMMUNOLOGY
Volume 2, Issue 10, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.26294
Keywords
regulatory T cells; cancer vaccines; alkylating chemotherapy; neo-antigens; chemoimmunotherapy
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Funding
- NCI NIH HHS [R01 CA160782] Funding Source: Medline
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Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative effect profoundly impairs vaccination-induced immune responses, especially in the case of vaccines that target specific tumor-associated neo-antigens that do not require Treg depletion.
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