Journal
ONCOIMMUNOLOGY
Volume 2, Issue 10, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.26260
Keywords
chaperone-mediated autophagy; calreticulin; damage-associated molecular patterns; dendritic cells; immunogenic cell death; photodynamic therapy; reactive oxygen species; T lymphocytes
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The inspection of the mechanisms through which autophagy modulates immunogenic cell death revealed that the autophagic response of cancer cells to reactive oxygen species-dependent endoplasmic reticulum stress suppresses the exposure of calreticulin on the cell surface, the phenotypic maturation of dendritic cells (DCs) as well as their ability to release interleukin-6 and to support the proliferative expansion of (interferon -producing) CD4(+) and CD8(+) T lymphocytes. These findings unveil an unprecedented role for therapy-induced autophagy in suppressing key mechanisms that underlie anticancer immune responses as elicited by immunogenic cell death.
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