The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma

The secretion of interleukin-10 by both malignant and immune cells promotes the progression of lung tumors, hence negatively impacting on patient prognosis. As interleukin-10 mediates oncogenic effects through the PI3K/AKt signaling pathway, PI3K/AKt inhibitors might sensitize cancer cells to chemotherapy, thus favoring tumor regression and improving disease outcome.