Neuroblastoma-related inflammation May small doses of aspirin be suitable for small cancer patients?

The daily intake of low-dose aspirin lowers the risk of several cancers among the adults. The continuous administration of low-dose aspirin to TH-MYCN mice (a model of pediatric neuroblastoma) delays tumor outgrowth and decreases tumor-promoting inflammation by inhibiting regulatory cells of the innate immune system as well as immunosuppressive mediators such as transforming growth factor (TGF) and thromboxane A(2). These findings pave novel avenues for the clinical management of neuroblastoma.