Journal
ONCOIMMUNOLOGY
Volume 2, Issue 5, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.24212
Keywords
oncolytic virus; measles virus vaccine; plasmacytoid DC; myeloid DC; cytotoxic CD8(+) T cell; tumor antigen
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Attenuated measles viruses (MV) are assessed in clinical trials for their capacity to preferentially infect and kill tumor cells. we recently showed that MV-infected tumor cells are able to activate tumor antigen cross-presentation by myeloid and plasmacytoid dendritic cells. thus, MV-based antitumor virotherapy may stimulate antitumor immune response.
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