Journal
ONCOIMMUNOLOGY
Volume 2, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.23563
Keywords
natural killer cells; lung cancer; mucosal antigen presentation; immunotherapy; adoptive immune system
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Funding
- ATS/Lungevity Foundation
- Alvin Siteman Cancer Center Internal Research Grant by The American Cancer Society
- NIH [K08CA131097, R01HL094601, R01HL113931, F32HL114270]
- Barnes Jewish Research Foundation
- Thoracic Surgery Foundation for Research and Education
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Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting.
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