Journal
ONCOIMMUNOLOGY
Volume 2, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.22731
Keywords
Mammaglobin-A; adoptive T-cell therapy; low dose irradiation; tumor eradication; CD8 T cells
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The major objectives of tumor vaccination are to induce the regression of established tumors and to favor the establishment of long-lasting tumor-specific immunity, capable of protecting the host from relapse. Immunotherapeutic strategies such as the administration of tumor-associated antigenic peptides offer one means to boost preexisting antitumor CD8(+) T cell immunity. Our recent work reveals that established breast tumors are rejected and tumor recurrence prevented when low-dose irradiation is combined with the adoptive transfer of Mammaglobin A epitope-specific CD8(+) T cells.
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