Journal
ONCOIMMUNOLOGY
Volume 2, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.22691
Keywords
adoptive cell therapy; cancer immunotherapy; checkpoint blockade; melanoma; PD-1; PD-L1
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Funding
- NCI NIH HHS [P30 CA016672] Funding Source: Medline
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The blockade of the PD-1 pathway can increase the production of interferon. by tumor-specific T cells located within or in the proximity of the malignant lesion, thereby increasing the chemokine-dependent trafficking of immune effector cells. This can boost the efficacy of adoptive T-cell therapy to achieve superior antitumor responses.
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