Journal
ONCOIMMUNOLOGY
Volume 2, Issue 12, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.26744
Keywords
dendritic cell; glycolysis; lactic acid; dendritic cell vaccine; dendritic cell differentiation
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We observed a cell concentration-dependent differentiation switch among cultured dendritic cells (DCs) triggered by lactic acid, a product of glycolytic metabolism. In particular, while interleukin (IL)-12, IL-23, and tumor necrosis factor alpha (TNF alpha)-producing, migratory DCs developed in sparse cultures, IL-10-producing, non-migratory DCs differentiated in dense cultures. This points to a novel opportunity for tailoring DC-based anticancer therapies through metabolism modulation in developing DCs.
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