Journal
ONCOIMMUNOLOGY
Volume 2, Issue 6, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.24572
Keywords
interferon; hematopoiesis; leukemia; hematopoietic stem cells; leukemia stem cells
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Interferons not only exert a fundamental role during inflammation and immune responses but also modulate the activity of hematopoietic stem cells during homeostatic and demand-adapted hematopoiesis. Identical mechanisms regulate the homeostasis and proliferation of leukemic stem cells (LSCs). Understanding these mechanisms may lead to novel therapeutic approaches against leukemia.
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