Journal
ONCOIMMUNOLOGY
Volume 2, Issue 9, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.25770
Keywords
gamma delta T cells; mevalonate pathway; immunogenic cell death; calreticulin; zoledronic acid; statins; multidrug resistance
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The mevalonate pathway is an attractive target for cancer therapy not only to override multidrug resistance but also to promote the immunogenic demise of malignant cells. recent data indicate that aminobisphosphonates are superior to statins for the pharmacological manipulation of the mevalonate pathway, since they exert therapeutically relevant effects on both cancer cells and the immune system.
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