Journal
ONCOIMMUNOLOGY
Volume 2, Issue 11, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.26442
Keywords
adaptive immunity; immunotherapy; innate immunity; interferon gamma; interleukin-15; memory CD8(+) T cells; myeloma; NKG2D; tumor
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Funding
- NCI NIH HHS [R44 CA156740, R43 CA156740, R43 CA167925] Funding Source: Medline
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ALT-803, an interleukin-15-based superagonist, induces memory CD8(+) T cells to proliferate, upregulate receptors involved in innate immunity, secrete interferon gamma and acquire the ability to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote the expansion and activation of memory CD8(+) T cells while converting them into innate immune effector cells that exhibit robust antineoplastic activity.
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