Journal
ONCOIMMUNOLOGY
Volume 2, Issue 3, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.23129
Keywords
EP2; EP4; immunosuppression; immunotherapy; mammary tumor; regulatory T cell
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High expression levels of cyclooxygenase 2 expression and infiltration by regulatory T cells (Tregs) are often associated with tumor progression. We have recently reported a prostaglandin E-2 (PGE(2))-dependent recruitment of Tregs to the tumor, suggesting that targeting specific PGE(2) receptors may constitute a valuable approach to ablate the immuno-editing that occurs along with disease progression.
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