Journal
ONCOIMMUNOLOGY
Volume 1, Issue 6, Pages 976-978Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.20059
Keywords
autophagosome; DAMP; c-type lectin; dendritic cells; cross-presentation
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It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-immunogenic; however, results from others and our laboratories suggest that autophagy is critically involved in immunogenic cell death.
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