Journal
ONCOIMMUNOLOGY
Volume 1, Issue 5, Pages 786-788Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.19750
Keywords
photodynamic therapy; calreticulin; ATP; phox-ER stress; immunogenic apoptosis
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Primary induction of photo-oxidative (phox)-ER stress in cancer cells evoked immunogenic apoptosis (IA) associated with pre-apoptotic emission of calreticulin and ATP, and protective antitumor immunity. This IA subroutine involved core functions (e.g., PERK/ PI3K-based modulation of secretory trafficking) rather than private ones (caspase-8 and eIF2 alpha-phosphorylation) engaged by other IA inducers.
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