Journal
ONCOIMMUNOLOGY
Volume 1, Issue 2, Pages 244-246Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.1.2.18309
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NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma. However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions. The possible mechanisms leading to these defects are discussed.
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