Journal
ONCOIMMUNOLOGY
Volume 1, Issue 3, Pages 392-394Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.19070
Keywords
anthracyclines; ATP release; immunogenic cell death; macroautophagy; oxaliplatin; cancer
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The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATP-degrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.
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