Journal
ONCOIMMUNOLOGY
Volume 1, Issue 2, Pages 252-254Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.1.2.18241
Keywords
tumor; dendritic cells; tolerance; Foxo3; immunotherapy
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Funding
- NIH, NCI
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Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potential target for immunotherapy.
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