Journal
ONCOIMMUNOLOGY
Volume 1, Issue 1, Pages 94-96Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.1.1.17885
Keywords
chemotherapy; necrosis; HMGB1; innate immunity; tumor associated macrophage
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Funding
- NCI NIH HHS [R01 CA129536] Funding Source: Medline
- NIGMS NIH HHS [R01 GM097355] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA129536] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM097355] Funding Source: NIH RePORTER
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The mechanism of tumor cell death after treatment with DNA alkylating agents in vivo previously remained largely unknown. We demonstrate that tumor regression after chemotherapy occurs via sporadic necrosis and relies on activation of innate immunity in a manner dependent on high mobility group box 1 protein (HMGB1).
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