Journal
ONCOIMMUNOLOGY
Volume 1, Issue 8, Pages 1425-1426Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.21173
Keywords
MIF; HSP90 inhibitors; breast cancer; client; CHIP
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Constitutively stabilized HSP90 client proteins are crucial for cancer cell survival and proliferation. Thus, despite-or perhaps because of-their pleiotropic effects on variety of critical oncoproteins, HSP90 inhibitors represent a promising new class of anticancer drugs. We identified MIF as an essential HSP90 client protein in a murine model of Her2-overexpressing breast cancer.
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