Journal
ONCOIMMUNOLOGY
Volume 1, Issue 4, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.19440
Keywords
Th17 cell; memory T cell; survival; apoptosis; stem cell; tumor immunity; IL-17; HIF; Notch; Bcl2
Categories
Funding
- NCI [CA152470, CA099985, CA156685]
- Ovarian Cancer Research Foundation
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Memory T cells are one of the most effective components of antitumor immunity. However, limited studies on cancer patients have not addressed the phenotypic, genetic and functional heterogeneity of memory T-cell subsets in the human cancer environments. Human IL-17(+)CD4(+) (Th17) cells are confined to memory T-cell compartment with CD45RO(+)CD62L(-)CCR7(-) phenotype and are enriched in CD49(+)CCR6(+) population. Th17 cells do not express PD-1, FoxP3, KLRG-1, CD57 and IL-10, making them unlikely candidates for being functionally exhausted PD-1(+) T cells or suppressive Foxp3(+) or IL-10(+) T cells or senescent CD28(-)CD57(+)KLRG-1(+) T cells. However, Th17 cells express high levels of CD95 and moderate levels of CD27. Th17 cells phenotypically resemble terminally differentiated memory T cells. Interestingly, Th17 cells possess polyfunctional cytokine profile, and have stem cell-like features. Th17 stemness may be partially controlled by signaling pathways of hypoxia inducible factor HIF1 alpha, Notch and Bcl. The stem cell-like character of Th17 cells is an important decisive factor for Th17 cell biology.
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