Journal
ONCOIMMUNOLOGY
Volume 1, Issue 9, Pages 1658-1660Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.22032
Keywords
dendritic cell; immunosurveillance; immunotherapy; multiple myeloma; T cell; T cell clones; Th17; Treg; trogocytosis
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Trogocytosis, which results in the acquisition of myeloma cell-derived membrane proteins by T cells, and hence generates novel regulatory T cells, adds to the growing list of immune defects of multiple myeloma patients. The increasing complexity of the cancer-associated immune defects must be attentively considered for attempting to improve the so-far unsatisfactory rates of clinical responses to immunotherapy in patients affected by multiple myeloma and other malignancies.
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