CD4 responses against IDO

Natural indoleamine-2,3-dioxygenase (IDO)-reactive CD4(+) T cells have been shown to release interferon gamma (IFN gamma), tumor necrosis factor alpha (TNF alpha), as well as interleukin 17 (IL-17). In some individuals, these cells also demonstrated the ability to suppress IL-10 production. IDO-specific CD4(+) helper T cells among peripheral blood lymphocytes may participate in immunoregulatory networks by delaying the immune suppressive actions of IDO. However, IDO-specific CD4(+) T cells may also have a regulatory phenotype, de facto exerting immunosuppressive functions.