Journal
ONCOIMMUNOLOGY
Volume 1, Issue 7, Pages 1211-1212Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.20780
Keywords
IDO; CD4; antigen; immune regulation; Th17; Th1
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Natural indoleamine-2,3-dioxygenase (IDO)-reactive CD4(+) T cells have been shown to release interferon gamma (IFN gamma), tumor necrosis factor alpha (TNF alpha), as well as interleukin 17 (IL-17). In some individuals, these cells also demonstrated the ability to suppress IL-10 production. IDO-specific CD4(+) helper T cells among peripheral blood lymphocytes may participate in immunoregulatory networks by delaying the immune suppressive actions of IDO. However, IDO-specific CD4(+) T cells may also have a regulatory phenotype, de facto exerting immunosuppressive functions.
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