Journal
ONCOIMMUNOLOGY
Volume 1, Issue 7, Pages 1159-1160Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.20825
Keywords
defensin; antimicrobial peptide; tumor growth; angiogenesis; lymphotoxin beta-receptor; chemokine receptor 6
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For many years, beta-defensins were best known for their antimicrobial activity. However, beta-defensins also exert immunomodulatory functions, such as the chemotactic recruitment of immune cells via chemokine receptors. We demonstrated that mouse beta-defensin 14 recruits CCR6(+) B cells into fibrosarcomas, resulting in enhanced angiogenesis and tumor development.
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