Journal
MOLECULAR METABOLISM
Volume 3, Issue 7, Pages 694-704Publisher
ELSEVIER
DOI: 10.1016/j.molmet.2014.07.002
Keywords
AgRP; Hypothalamus; Food anticipatory activity (FAA); Food entrainable oscillator (FEO)
Categories
Ask authors/readers for more resources
While the SCN controls the circadian clock, further evidence suggests the existence of a food-entrainable oscillator (FED) that links behavior to changes in food availability such as during restricted feeding (RF). We found that the activity of AgRP/NPY neurons changed rhythmically during RF suggesting that these neurons are a component of the FEO. We next ablated AgRP/NPY neurons in neonates with diphtheria toxin resulting in the loss of similar to 50% of AgRP/NPY neurons. Body weight and food intake were unchanged in adult animals after neonatal ablation, as were the responses to leptin treatment, leptin withdrawal, food deprivation and ghrelin treatment. However, ablated animals showed 30% mortality within 4 days of RF. Moreover, the recovery of body weight and food intake in surviving animals lagged behind controls with an absence of food anticipatory activity even after three days. These findings identify AgRP/NPY neurons as a key cellular component of the food-entrained oscillator. (C) 2014 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http.creativecommons.org/licenses/by-nc-nd/3.0/).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available