Journal
MOLECULAR METABOLISM
Volume 2, Issue 3, Pages 215-226Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molmet.2013.05.004
Keywords
Peroxisome proliferator-activated receptor gamma coactivator-1; Mitochondrial biogenesis; Adipocytes; Thiazolidinediones; Type 2 diabetes
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Funding
- NIDDK NIH HHS [R01 DK095686] Funding Source: Medline
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Proper development and function of white adipose tissue (WAT), which are regulated by multiple transcription factors and coregulators, are crucial for glucose homeostasis. WAT is also the main target of thiazolidinediones, which are thought to exert their insulin-sensitizing effects by promoting mitochondrial biogenesis in adipocytes. Besides being expressed in WAT, the role of the coactivator PGC-1 beta in this tissue has not been addressed. To study its function in WAT, we have generated mice that lack PGC-1 beta in adipose tissues. Gene expression profiling analysis of WAT reveals that PGC-1 beta regulates mitochondria) genes involved in oxidative metabolism. Furthermore, lack of PGC-1 beta prevents the induction of mitochondrial genes by rosiglitazone in WAT without affecting the capacity of thiazolidinediones to enhance insulin sensitivity. Our findings indicate that PGC-1 beta is important for basal and rosiglitazone-induced mitochondrial function in WAT, and that induction of mitochondrial oxidative capacity is not essential for the insulin-sensitizing effects of thiazolidinediones. (C) 2013 Elsevier GmbH. Open access under CC BY-NC-ND license
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