Journal
SPRINGERPLUS
Volume 4, Issue -, Pages -Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1186/s40064-015-0786-0
Keywords
Onion peel extract; Quercetin; Platelet aggregation; Intracellular Ca2+; Cyclic adenosine monophosphate; Thromboxane A(2)
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Funding
- Korea Foundation for the Advancement of Science & Creativity (KOFAC) - Korean Government (MOE) [20140021C9I0101S000100]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2010-0024028]
- National Research Foundation of Korea [2010-0024028] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The effects of onion peel extract (OPE) in collagen (5 mu g/mL)-stimulated washed rat platelet aggregation were investigated. OPE inhibited platelet aggregation via inhibition of aggregation-inducing molecules, intracellular Ca2+ and thromboxane A(2) (TXA(2)) by blocking cyclooxygenase-1 (COX-1) and TXA(2) synthase (TXAS) activities in a dose-dependent manner. In addition, OPE elevated the formation of cyclic adenosine monophosphate (cAMP), aggregation-inhibiting molecule, but not cyclic guanosine monophosphate (cGMP). High performance liquid chromatography (HPLC) analysis of OPE revealed that OPE contains quercetin, one of the major flavonoids, which has anti-platelet effect. In conclusion, we suggest that OPE is an effective inhibitor of collagen-stimulated platelet aggregation in vitro. Therefore, it can be a promising and safe strategy for anti-cardiovascular diseases.
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