Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 456, Issue 1, Pages 305-311Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.11.076
Keywords
Autophagy; ER stress; IRE1; PERK; Unfolded protein response (UPR)
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Funding
- Science Foundation Ireland [06/RFP/BIC002, 05/IN3/B851]
- Health Research Board [HRA_HSR/2010/24]
- Belgian Grant - Interuniversity Attraction Poles [IAP 7/32]
- College of Science at NUIG
- Science Foundation Ireland (SFI) [06/RFP/BIC002, 05/IN3/B851] Funding Source: Science Foundation Ireland (SFI)
- Health Research Board (HRB) [HRA-HSR-2010-24] Funding Source: Health Research Board (HRB)
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Endoplasmic reticulum (ER) stress is known to lead to activation of both the unfolded protein response (UPR) and autophagy. Although regulatory connections have been identified between the UPR and autophagy, it is still unclear to what extent the UPR regulates the genes involved at the different stages of the autophagy pathway. Here, we carried out a microarray analysis of HCT116 cells subjected to ER stress and observed the transcriptional upregulation of a large cohort of autophagy-related genes. Of particular interest, we identified the transcriptional upregulation of the autophagy receptor genes SQSTM1/p62, NBR1 and BNIP3L/NIX in response to ER stress and show that the inhibition of the UPR transmembrane receptors, PERK and IRE1, abrogates this upregulation. (C) 2014 Elsevier Inc. All rights reserved.
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