Journal
JOURNAL OF CELL COMMUNICATION AND SIGNALING
Volume 4, Issue 3, Pages 157-158Publisher
SPRINGER
DOI: 10.1007/s12079-010-0096-9
Keywords
CTGF; Nicotine; Smoking; Betel nuts; Oral fibrosis; Gingiva
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Smoking causes oral fibrosis. In a recent report, Takeuchi and colleagues (J Dent Res 89: 34-9, 2010) evaluate whether nicotine can directly elevate collagen production in gingival fibroblasts. They show that CCN2 (connective tissue growth factor, CTGF) is elevated in response to nicotine and that a neutralizing CCN2 antibody reduces the ability of nicotine to promote collagen production. These data suggest that nicotine from smoking may promote periodontal fibrosis via CCN2. This commentary summarizes these findings.
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