Journal
JOURNAL OF CELL COMMUNICATION AND SIGNALING
Volume 3, Issue 3-4, Pages 239-246Publisher
SPRINGER
DOI: 10.1007/s12079-009-0062-6
Keywords
BM-40; Collagen; Fibrillogenesis; Osteonectin; Review
Categories
Funding
- Veteran's Administration
- NIDCR, NIH [P20 2P20RR017696-07]
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SPARC is a collagen-binding matricellular protein. Expression of SPARC in adult tissues is frequently associated with excessive deposition of collagen and SPARC-null mice fail to generate a robust fibrotic response to a variety of stimuli. This review summarizes recent advancements in the characterization of the binding of SPARC to collagens and describes the results of studies that implicate a function for SPARC in the regulation of the assembly of basal lamina and fibrillar collagen in the ECM. Potential cellular mechanisms that underlie SPARC activity in ECM deposition are also explored.
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