Journal
JOURNAL OF CELL COMMUNICATION AND SIGNALING
Volume 3, Issue 3-4, Pages 201-213Publisher
SPRINGER
DOI: 10.1007/s12079-009-0070-6
Keywords
Matricellular proteins; Thrombospondin; Heart failure; Hypertrophy; Myocardial infarction
Categories
Funding
- Netherlands Heart Foundation [NHS 2005B082, NHS 2007B036, 2008B011]
- Dutch Research Foudation
Ask authors/readers for more resources
Cardiac remodeling after myocardial injury involves inflammation, angiogenesis, left ventricular hypertrophy and matrix remodeling. Thrombospondins (TSPs) belong to the group of matricellular proteins, which are nonstructural extracellular matrix proteins that modulate cell-matrix interactions and cell function in injured tissues or tumors. They interact with different matrix and membrane-bound proteins due to their diverse functional domains. That the expression of TSPs strongly increases during cardiac stress or injury indicates an important role for them during cardiac remodeling. Recently, the protective properties of TSP expression against heart failure have been acknowledged. The current review will focus on the biological role of TSPs in the ischemic and hypertensive heart, and will describe the functional consequences of TSP polymorphisms in cardiac disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available