Journal
JOURNAL OF CELL COMMUNICATION AND SIGNALING
Volume 3, Issue 1, Pages 61-64Publisher
SPRINGER
DOI: 10.1007/s12079-009-0053-7
Keywords
Perictytes; CTGF; CCN2
Categories
Funding
- Arthritis Research Campaign
- Reynaud's and Scleroderma Association
- Canadian Institute of Heath Research
- Canadian Foundation for Innovation
- Scleroderma Society
- Early Researcher Award
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By providing a source of alpha-smooth muscle actin (alpha -SMA)-expressing myofibroblasts, microvascular pericytes contribute to the matrix remodeling that occurs during tissue repair. However, the extent to which pericytes may contribute to the fibroblast phenotype post-repair is unknown. In this report, we test whether pericytes isolated from human placenta can in principle become fibroblast-like. Pericytes were cultured in vitro for 11 passages. The Affymetrix mRNA expression profile of passage 2 and passage 11 pericytes was compared. The expression of type I collagen, thrombospondin and fibronectin mRNAs was induced by passaging pericytes in culture. This induction of a fibroblast phenotype was paralleled by induction of connective tissue growth factor (CTGF/CCN2) and type I collagen protein expression and the fibroblast marker ASO2. These results indicate that, in principle, pericytes have the capacity to become fibroblast-like and that pericytes may contribute to the population of fibroblasts in a healed wound.
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