Journal
JOURNAL OF CELL COMMUNICATION AND SIGNALING
Volume 4, Issue 1, Pages 71-72Publisher
SPRINGER
DOI: 10.1007/s12079-009-0079-x
Keywords
cyr 61; CTGF; CCN proteins; CCN1; Cancer; Prostate; Matricellular proteins; Adhesion
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Members of the CCN family of matricellular signaling regulators promote cell adhesion through integrins and heparan sulfate-containing proteoglycans. A paradox of the CCN field is that, depending on the set of circumstances examined, individual CCN molecules can have quite different, and often opposing, effects. In a recent report, Franzen and colleagues (Mol Cancer Res. 7:1045-1055, 2009) show using siRNA knockdown that CCN1 (cyr61) is essential for the proliferation of prostate cancer cells. Intriguingly, on the other hand, CCN1 also enhances TRAIL-induced apoptosis. Thus the utility of anti-CCN1 therapy in cancer needs to be carefully considered in light of these divergent results. The significance of this paper is discussed.
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