Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
Volume 2, Issue 6, Pages 664-670Publisher
ELSEVIER
DOI: 10.1016/j.jaip.2014.09.010
Keywords
Asthma risk; Wheezing; Childhood asthma; Asthma phenotypes; Asthma epidemiology childhood; Biomarkers; Genetics; Review
Categories
Funding
- Teva
- GlaxoSmithKline
- Regeneron Pharmaceuticals
- Center for Disease Control
- DHHS
- National Institutes of Health
- Abbott Laboratories
- Array Biopharma
- Mylan
- Forest Research Institute
- F Hoffman-LaRoche
- Development Limited
- MedImmune
- KaloBios Pharmaceuticals
- Vertez Pharmaceuticals
- Roxane Laboratories
- CF Foundation Therapeutics
- Roche/Genentech
- Merck
- Boehringer Ingelheim
- NHLBI
- Program Project Grant (COAST)
- AsthmaNet
- Lung Development Grant (RO-1)
- Sepracor
- SA Boney and Associates
- American Institute of Research
- Genentech
- Double Helix Development
- Health Star Communications
- Pharmaxis
- Michigan Public Health
- Allegheny General Hospital
- AAP
- West Allegheny Health
- California Chapter 4
- Colorado Allergy Society
- Pennsylvania Allergy Society
- Howard Pilgrim Health
- California Society of Allergy
- NYC Allergy Society
- World Allergy Organization
- APAPARI
- Western Society of Allergy Asthma and Immunology
- Kuwait Allergy Society
- Lurie Children's Hospital
- Boston Children's Hospital
- LA Children's Hospital
- Northwestern University
- AAAAI
- University of Wisconsin Madison Medical and Education Research Committee
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Wheezing is a fairly common symptom in early childhood, but only some of these toddlers will experience continued wheezing symptoms in later childhood. The definition of the asthma-predictive phenotype is in children with frequent, recurrent wheezing in early life who have risk factors associated with the continuation of asthma symptoms in later life. Several asthma-predictive phenotypes were developed retrospectively based on large, longitudinal cohort studies; however, it can be difficult to differentiate these phenotypes clinically as the expression of symptoms, and risk factors can change with time. Genetic, environmental, developmental, and host factors and their interactions may contribute to the development, severity, and persistence of the asthma phenotype over time. Key characteristics that distinguish the childhood asthma-predictive phenotype include the following: male sex; a history of wheezing, with lower respiratory tract infections; history of parental asthma; history of atopic dermatitis; eosinophilia; early sensitization to food or aeroallergens; or lower lung function in early life. (C) 2014 American Academy of Allergy, Asthma & Immunology
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