Journal
REDOX BIOLOGY
Volume 6, Issue -, Pages 260-271Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2015.08.010
Keywords
Calcium; Reactive oxygen species; Mitochondria; NADPH oxidases; Endoplasmic reticulum; Channels
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Funding
- European Cooperation in Science and Technology (COST Action) [BM1203/EU-ROS]
- DZHK (German Centre for Cardiovascular Research)
- German Research Foundation [DFG-GO709/4-5]
- German Federal Ministry of Education and Research (Acidox, Epiros)
- Vedecka Grantova Agentura MSVVaS SR [SAV 2/0074]
- CEMAN
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Calcium is an important second messenger involved in intra- and extracellular signaling cascades and plays an essential role in cell life and death decisions. The Ca2+ signaling network works in many different ways to regulate cellular processes that function over a wide dynamic range due to the action of buffers, pumps and exchangers on the plasma membrane as well as in internal stores. Calcium signaling pathways interact with other cellular signaling systems such as reactive oxygen species (ROS). Although initially considered to be potentially detrimental byproducts of aerobic metabolism, it is now clear that ROS generated in sub-toxic levels by different intracellular systems act as signaling molecules involved in various cellular processes including growth and cell death. Increasing evidence suggests a mutual interplay between calcium and ROS signaling systems which seems to have important implications for fine tuning cellular signaling networks. However, dysfunction in either of the systems might affect the other system thus potentiating harmful effects which might contribute to the pathogenesis of various disorders. (C) 2015 The Authors. Published by Elsevier B.V.
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