Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

Cancer formation is a complex and highly regulated multi step process which is highly dependent of its environment, from the tissue to the patient. This complexity implies the development of specific treatments adapted to each type or tumor. The initial step or cancer formation requires the transformation of a healthy cell to a cancer cell, a process regulated by multiple intracellular and extracellular stimuli. The further steps, from the anarchic proliferation of cancer cells to form a primary tumor to the migration of cancer cells to distant organs to form metastasis, are also highly dependent of the tumor environment but of intracellular molecules and pathways as well. In this review, we will focus on the regulatory role of reactive oxygen species (ROS) and autophagy levels during the course of cancer development, from cellular transformation to the formation of metastasis. These data will allow us to discuss the potential of this molecule or pathway as putative future therapeutic targets. (C) 2014 The Authors. Published by Elsevier B.V.