Journal
REDOX BIOLOGY
Volume 6, Issue -, Pages 648-655Publisher
ELSEVIER
DOI: 10.1016/j.redox.2015.10.010
Keywords
Oxidative stress; Reproductive toxicity; Auranofin; Zebrafish; Longitudinal cohort
Categories
Funding
- Dunedin School of Medicine Research Development Investment Award
- Maurice Wilkins Centre Flexible Research Seeding Programme
- Maurice and Phyllis Paykel Trust
- University of Otago Doctoral Scholarship
- Gravida National Centre for Growth and Development
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Exposure to environmental stressors during embryo development can have long-term effects on the adult organism. This study used the thioredoxin reductase inhibitor auranofin to investigate the consequences of oxidative stress during zebrafish development. Auranofin at low doses triggered upregulation of the antioxidant genes gstp1 and prdx1. As the dose was increased, acute developmental abnormalities, including cerebral hemorrhaging and jaw malformation, were observed. To determine whether transient disruption of redox homeostasis during development could have long-term consequences, zebrafish embryos were exposed to a low dose of auranofin from 6-24 hours post fertilization, and then raised to adulthood. The adult fish were outwardly normal in their appearance with no gross physical differences compared to the control group. However, these adult fish had reduced odds of breeding and a lower incidence of egg fertilization. This study shows that a suboptimal early life environment can reduce the chances of reproductive success in adulthood. (C) 2015 The Authors. Published by Elsevier B.V.
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