Journal
FUNGAL BIOLOGY REVIEWS
Volume 28, Issue 2-3, Pages 56-69Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.fbr.2014.02.004
Keywords
Aspergillus; Calcineurin; Candida; Cell wall; Fungi; Septum; Virulence
Categories
Funding
- NIH/NIAID [R56 AI077648-01A2, R21 AI097541-01A1]
- Swiss Foundation for Medical-Biological Grants
- Swiss National Science Foundation [PASMP3-142746]
- Swiss National Science Foundation (SNF) [PASMP3_142746] Funding Source: Swiss National Science Foundation (SNF)
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Calcineurin signaling plays diverse roles in fungi in regulating stress responses, morphogenesis and pathogenesis. Although calcineurin signaling is conserved among fungi, recent studies indicate important divergences in calcineurin-dependent cellular functions among different human fungal pathogens. Fungal pathogens utilize the calcineurin pathway to effectively survive the host environment and cause life-threatening infections. The immunosuppressive calcineurin inhibitors (FK506 and cyclosporine A) are active against fungi, making targeting calcineurin a promising antifungal drug development strategy. Here we summarize current knowledge on calcineurin in yeasts and filamentous fungi, and review the importance of understanding fungal-specific attributes of calcineurin to decipher fungal pathogenesis and develop novel antifungal therapeutic approaches. (C) 2014 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.
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