Journal
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
Volume 5, Issue 2, Pages 205-208Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.preghy.2015.03.001
Keywords
Preeclampsia; Adiponectin; Leptin; Metalloproteinase (MMP)-2 and (MMP)-9; Tissue inhibitor of metalloproteinase (TIMP)-1 and (TIMP)-2
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq-Brazil)
- Fundacao o de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP-Brazil)
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Objective: The aims of the present study were to compare plasma concentrations of the adiponectin, leptin, metalloproteinases (MMP9 and MMP2) and its tissue inhibitors (TIMP1 and TIMP2) in preeclamptic (PE) and healthy pregnant (HP) groups and correlate them. Methods: A total of 105 pregnant women with pre-pregnancy body mass index (BMI) values <= 30 kg/m(2) were enrolled for this study (59 PE and 46 HP). Biomarkers were measured using ELISAs. Results: Adiponectin (32%), leptin (45%), MMP2 (20%), TIMP1 (31%) and TIMP2 (23%) levels were higher in PE compared to HP (all P < 0.05). In addition there were positive correlations between adiponectin and MMP2 (r = 0.33; P = 0.03) and adiponectin and TIMP2 (r = 0.33; P = 0.03) in PE group, but not in HP. Conclusion: Our findings show that adiponectin, leptin, MMP2, TIMP1 and TIMP2 levels are increased in PE and adiponectin may contribute to higher levels of MMP2 and TIMP2 in this disease. (C) 2015 International Society for the Study of Hypertension in Pregnancy Published by Elsevier B.V. All rights reserved.
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