Journal
FRONTIERS IN IMMUNOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fimmu.2014.00010
Keywords
V(D)J recombination; VH replacement; VH; DH; and JH gene segments; receptor editing
Categories
Funding
- Arthritis Foundation
- Lupus Research Institute
- Hematology Translational Center of Excellence at the Perelman School of Medicine of the University of Pennsylvania
- NIH [T32 CA009615, R25-DK066028]
- Institute for Translational Medicine and Therapeutics at the University of Pennsylvania
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VH replacement (VHR) is a type of antibody gene rearrangement in which an upstream heavy chain variable gene segment (VH) invades a pre-existing rearrangement (VDJ). In this Hypothesis and Theory article, we begin by reviewing the mechanism of VHR, its developmental timing and its potential biological consequences. Then we explore the hypothesis that specific sequence motifs called footprints reflect VHR versus other processes. We provide a compilation of footprint sequences from different regions of the antibody heavy chain, and include data from the literature and from a high throughput sequencing experiment to evaluate the significance of footprint sequences. We conclude by discussing the difficulties of attributing footprints to VHR.
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