Journal
FRONTIERS IN IMMUNOLOGY
Volume 5, Issue -, Pages 1-10Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2014.00389
Keywords
suppressor T-cells; NK cells; cancer tolerance; Treg; evolution of the immune system
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In this review, we first revisit the original concept of suppressor T-cells in pregnancy, put it in a historical perspective, and then highlight the main data that licensed its resurrection and revision into the concept of regulatory T-cells (Tregs) in pregnancy. We review the evidence for a major role of Tregs in murine and human pregnancy and discuss Treg interactions with dendritic and uterine natural killer cells, other players of maternal fetal tolerance. Finally, we highlight what we consider as the most important questions in the field.
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