Journal
FRONTIERS IN IMMUNOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2014.00641
Keywords
T-cell metabolism; fatty acid oxidation; oxidative phosphorylation; reactive oxygen species (ROS); AMP-activated protein kinase; graft-versus-host disease; in vivo models
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Funding
- National Cancer Institute [5PO1-CA039542]
- National Institutes of Health-sponsored Child Health Research Centers [5K12-HD028820]
- Hyundai Motor Company
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Activation represents a significant bioenergetic challenge for T-cells, which must undergo metabolic reprogramming to keep pace with increased energetic demands. This review focuses on the role of fatty acid metabolism, both in vitro and in vivo, following T-cell activation. Based upon previous studies in the literature, as well as accumulating evidence in allogeneic cells, I propose a multi-step model of in vivo metabolic reprogramming. In this model, a primary determinant of metabolic phenotype is the ubiquity and duration of antigen exposure. The implications of this model, as well as the future challenges and opportunities in studying T-cell metabolism, will be discussed.
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