Journal
FRONTIERS IN IMMUNOLOGY
Volume 5, Issue -, Pages 1-4Publisher
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fimmu.2014.00112
Keywords
T/APC interaction; trogocytosis; T cell activation; costimulation; immune regulation
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It was recently proposed that T lymphocytes, which closely interact with APCs, can extract surface molecules from the presenting cells when they dissociate. These observations question the classical view of discrete interactions between phenotypically defined cell populations. In this review, we summarize some reports suggesting that membrane exchange at the immune synapse can be a vector for intercellular communication and envisage some consequences on the biology of T cells.
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