Journal
FRONTIERS IN IMMUNOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2014.00384
Keywords
IDO; viral infection; bacterial infection; depressive disorders; kyn metabolites
Categories
Funding
- DFG [Sonderforschungsbereich 645, SFB 704, SFB 832, INST 217/575-1, INST 217/576-1, INST 217/577-1]
- European Union [317445]
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Initially, indoleamine-2,3-dioxygenase (IDO) has been introduced as a bactericidal effector mechanism and has been linked to T-cell immunosuppression and tolerance. In recent years, evidence has been accumulated that IDO also plays an important role during viral infections including HIV, influenza, and hepatitis B and C. Moreover, novel aspects about the role of IDO in bacterial infections and sepsis have been revealed. Here, we review these recent findings highlighting the central role of IDO and tryptophan metabolism in many major human infections. Moreover, we also shed light on issues concerning human-specific and mouse-specific host pathogen interactions that need to be considered when studying the biology of IDO in the context of infections.
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